Related Experiment Video
Updated: Jun 30, 2026

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
Published on: May 4, 2015
Infarction-exclusion technique with the on-pump beating heart approach for ventricular septal perforation
Takeshi Shimamoto1, Akira Marui, Yoshiaki Saji
1Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan. shimamo@kuhp.kyoto-u.ac.jp
Insights
This study presents a successful surgical repair of post-heart attack ventricular septal defects using an innovative infarction-exclusion technique. The on-pump beating heart method with bypass grafting minimized heart muscle damage and improved repair outcomes.
Area of Science:
- Cardiovascular Surgery
- Cardiac Surgery Techniques
- Myocardial Infarction Complications
Background:
- Post-infarction ventricular septal perforation is a life-threatening complication requiring complex surgical intervention.
- Traditional surgical approaches may involve significant myocardial damage and suboptimal outcomes.
- Minimizing myocardial injury during repair is crucial for patient survival and recovery.
Observation:
- The study details the surgical management of a patient with postinfarction ventricular septal perforation.
- An infarction-exclusion technique was employed using an on-pump beating heart approach.
- Concomitant coronary artery bypass grafting was performed during the repair procedure.
Findings:
- The infarction-exclusion technique, combined with direct suture line assessment, accurately identified viable myocardium for patch support.
- The on-pump beating heart strategy minimized cardioplegia-induced myocardial damage.
- Successful surgical repair of the ventricular septal perforation was achieved.
Implications:
- This surgical approach offers a potentially safer and more effective method for managing post-infarction ventricular septal defects.
- Minimizing myocardial damage during complex cardiac surgery can lead to improved patient outcomes.
- The technique highlights the benefits of on-pump beating heart surgery in specific complex cardiac repairs.
Abstract:
We report a successful surgical management of postinfarction ventricular septal perforation by infarction-exclusion technique with the on-pump beating heart approach and concomitant coronary artery bypass grafting. The identification of the suture line by direct inspection and finger palpation could be more accurate in determining contractile, thus viable myocardium supporting the patch, and concomitant coronary artery bypass grafting with on-pump beating heart could minimize the cardioplegia-induced myocardial damage.
