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Risk factors for a first thrombotic event in antiphospholipid antibody carriers. A multicentre, retrospective

A Ruffatti1, T Del Ross, M Ciprian

  • 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy. amelia.ruffatti@unipd.it

Annals of the Rheumatic Diseases
|September 25, 2008
PubMed

Insights

Antiphospholipid antibody (aPL) carriers with hypertension or high IgG anticardiolipin antibody (aCL) levels face increased thrombosis risk. Prophylactic treatment significantly reduces this risk in asymptomatic individuals.

Area of Science:

  • Rheumatology
  • Hematology
  • Immunology

Background:

  • Antiphospholipid antibodies (aPL) are associated with an increased risk of thrombosis.
  • Identifying risk factors and effective prophylactic strategies in asymptomatic aPL carriers is crucial.

Purpose of the Study:

  • To identify risk factors for a first thrombotic event in antiphospholipid antibody (aPL) positive individuals.
  • To evaluate the efficacy of prophylactic treatments in preventing thrombosis.

Main Methods:

  • Retrospective analysis of 370 patients aged 18-65 years with confirmed lupus anticoagulant and/or anticardiolipin antibodies (aCL).
  • Data collection included demographic, laboratory, and clinical parameters, with a mean follow-up of 59.3 months.
  • Multivariate logistic regression was used to identify independent risk factors.

Main Results:

  • A total of 30 patients (8.1%) experienced a first thrombotic event during follow-up.
  • Hypertension and medium/high levels of IgG aCL were identified as independent risk factors for thrombosis.
  • Thromboprophylaxis administered during high-risk and long-term periods demonstrated significant protective effects.

Conclusions:

  • Hypertension and medium/high IgG aCL titers are significant risk factors for first thrombotic events in asymptomatic aPL carriers.
  • Primary prophylaxis is effective in protecting asymptomatic aPL carriers from thrombotic events.
Abstract

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