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Related Experiment Video

Updated: Jun 30, 2026

Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Navigating from hippocampus to parietal cortex.

Jonathan R Whitlock1, Robert J Sutherland, Menno P Witter

  • 1Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, 7489 Trondheim, Norway.

Proceedings of the National Academy of Sciences of the United States of America
|September 25, 2008
PubMed
Summary
This summary is machine-generated.

The posterior parietal cortex is crucial for translating spatial navigation information into movement commands. This brain region helps animals direct locomotion by converting coordinate data into body-centered representations.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Computational Neuroscience

Background:

  • Mammalian navigation relies on a network of interacting cortical regions.
  • Grid cells (medial entorhinal cortex) and place cells (hippocampus) form dynamic spatial representations crucial for memory.
  • Translating spatial maps into motor commands for locomotion is a key, yet unexplained, aspect of navigation.

Purpose of the Study:

  • To investigate the role of the posterior parietal cortex in spatial navigation.
  • To elucidate the mechanism by which coordinate information is transformed for locomotion.
  • To propose a model for how the brain directs movement based on environmental mapping.

Main Methods:

  • This study proposes a theoretical framework based on existing literature.
  • It integrates findings from research on grid cells, place cells, and parietal cortex function.
  • The approach involves conceptual synthesis rather than novel experimental data.

Main Results:

  • The posterior parietal cortex is hypothesized to be critical for transforming allocentric spatial information into egocentric motor commands.
  • This transformation enables the translation of 'where am I?' (spatial mapping) into 'how do I move?' (locomotion).
  • The proposed function highlights the parietal cortex's role as a crucial interface between spatial cognition and motor control.

Conclusions:

  • The posterior parietal cortex plays a pivotal role in sensorimotor integration for navigation.
  • Understanding this transformation is key to deciphering the neural basis of goal-directed movement.
  • This work opens avenues for future research into the neural circuits underlying spatial navigation and action.