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Quantification of Acanthamoeba spp. Motility
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Published on: September 20, 2024

Acanthamoeba keratitis presenting as a plaque.

Srikant K Sahu1, Sujata Das, Savitri Sharma

  • 1Cornea & Anterior Segment Service, LV Prasad Eye Institute, Bhubaneswar, Orissa, India.

Cornea
|September 25, 2008
PubMed
Summary
This summary is machine-generated.

Acanthamoeba keratitis can mimic fungal infections with plaque-like corneal lesions. Early diagnosis and treatment, including plaque removal, are crucial for resolving this serious eye infection.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Acanthamoeba keratitis (AK) is a severe microbial infection of the cornea.
  • It often presents with non-specific symptoms, leading to delayed diagnosis.
  • Distinguishing AK from other microbial keratitis, such as fungal keratitis, is clinically challenging.

Observation:

  • A case of a 55-year-old woman with a corneal plaque-like lesion, initially suspected to be fungal keratitis.
  • The lesion was characterized by a yellow plaque surrounded by corneal infiltrate.
  • Diagnostic procedures included corneal smears, culture, and histopathological examination of the removed plaque.

Findings:

  • Microscopic and histopathological analyses confirmed the presence of Acanthamoeba cysts.
  • The patient received intensive topical antimicrobial therapy.
  • Complete resolution of the Acanthamoeba keratitis was achieved after 8 weeks of treatment.

Implications:

  • This case highlights that Acanthamoeba keratitis can present with atypical, plaque-like lesions resembling fungal keratitis.
  • Surgical debridement (plaque removal) may aid in the prompt resolution of infection.
  • Ophthalmologists should consider Acanthamoeba in the differential diagnosis of unusual corneal lesions, even those mimicking fungal infections.