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Related Experiment Video

Updated: Jun 30, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
07:40

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Published on: January 26, 2019

The Sleep Heart Health Study: a progress report.

Daniel J Gottlieb1

  • 1VA Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA. gottlieb@bu.edu

Current Opinion in Pulmonary Medicine
|September 25, 2008
PubMed
Summary

Cross-sectional data from the Sleep Heart Health Study reveal key insights into sleep disorders and cardiovascular disease. Findings link sleep apnea to hypertension and cardiac changes, and restless legs syndrome to prevalent cardiovascular issues.

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Area of Science:

  • Sleep Medicine
  • Cardiovascular Disease Research
  • Epidemiology

Background:

  • The Sleep Heart Health Study (SHHS) initiated in 1994 as a prospective cohort study.
  • Focuses on the relationship between cardiovascular disease and sleep.
  • While longitudinal analyses are pending, cross-sectional data have yielded significant findings.

Purpose of the Study:

  • To review and summarize key findings from cross-sectional analyses of the Sleep Heart Health Study.
  • To provide an overview of the study's contributions to sleep medicine and cardiovascular research.

Main Methods:

  • Analysis of cross-sectional data from the Sleep Heart Health Study.
  • Methodological validation for identifying hypopneas using a 4% oxyhemoglobin desaturation criterion.
  • Genome-wide association study (GWAS) of sleep and circadian phenotypes.

Main Results:

  • Sleep apnea is associated with increased left ventricular mass, suggesting eccentric hypertrophy.
  • Sleepiness may influence the link between sleep apnea and hypertension.
  • Restless legs syndrome is associated with a higher prevalence of cardiovascular disease.
  • Methodological study supports the 4% oxyhemoglobin desaturation criterion for hypopnea identification.

Conclusions:

  • Cross-sectional data analysis from the SHHS has provided substantial contributions to sleep medicine.
  • Despite its prospective design, the study's cross-sectional findings offer valuable insights into sleep and cardiovascular health.