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Related Experiment Videos

Echo-planar imaging of diffusion and perfusion.

R Turner1, D Le Bihan, A S Chesnick

  • 1Biomedical Engineering and Instrumentation Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.

Magnetic Resonance in Medicine
|June 1, 1991
PubMed
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Echo-planar diffusion imaging overcomes motion artifacts in brain scans, enabling accurate measurement of the diffusion coefficient. This technique reveals a significant perfusion fraction in human grey matter, indicating approximately 10% extracellular volume.

Area of Science:

  • Neuroimaging
  • Biophysics

Background:

  • Diffusion imaging in the brain is prone to motion artifacts.
  • The Stejskal-Tanner sequence is often complicated by pulsatile motion.

Purpose of the Study:

  • To implement echo-planar diffusion imaging to mitigate motion artifacts.
  • To enable reproducible in vivo measurement of the diffusion coefficient.
  • To quantify perfusion effects in brain tissue.

Main Methods:

  • Utilized echo-planar diffusion imaging technique.
  • Performed diffusion imaging on a phantom and in the human brain.
  • Measured quantitative diffusion coefficient values in vivo.

Main Results:

  • Echo-planar diffusion imaging successfully avoided motion artifacts.

Related Experiment Videos

  • Reproducible diffusion coefficient measurements were achieved.
  • A significant perfusion fraction of approximately 10% was observed in human grey matter.

    • Conclusions:

    • Echo-planar diffusion imaging is a robust method for brain diffusion studies.
    • The technique allows for accurate in vivo diffusion coefficient measurement.
    • Findings suggest a notable extracellular/microvascular volume in grey matter.