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Related Experiment Videos

Contrast agents and cerebral hemodynamics.

B R Rosen1, J W Belliveau, B R Buchbinder

  • 1MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Boston.

Magnetic Resonance in Medicine
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

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This study explores contrast-enhanced MRI for measuring regional cerebral hemodynamics, including cerebral blood volume (CBV) and flow. Techniques validated in animals are now applied to human studies, addressing challenges in pathologic tissues.

Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • Assessing regional cerebral hemodynamics is crucial for understanding brain function and disease.
  • Contrast-enhanced magnetic resonance imaging (MRI) offers advanced capabilities for hemodynamic assessment.

Purpose of the Study:

  • To discuss contrast-enhanced MRI techniques for evaluating regional cerebral hemodynamics.
  • To present the validation and application of cerebral blood volume (CBV) measurement techniques.
  • To explore the extension of these techniques for cerebral blood flow (CBF) assessment.

Main Methods:

  • Utilized contrast-enhanced MRI to assess regional cerebral hemodynamics.
  • Validated techniques for measuring cerebral blood volume (CBV) in animal models.

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  • Applied CBV measurement techniques to human studies, considering factors in pathologic tissues.

    • Main Results:

    • CBV measurement techniques have been successfully validated in animal models.
    • These techniques have been effectively applied to human studies.
    • Factors influencing CBV measurement in pathologic tissues were identified and addressed.

    Conclusions:

    • Contrast-enhanced MRI is a viable tool for assessing regional cerebral hemodynamics.
    • Validated CBV measurement techniques can be extended to measure cerebral blood flow.
    • Further research can refine these methods for clinical applications in cerebrovascular diseases.