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Localized 1H NMR spectroscopy in Canavan's disease: a report of two cases
S J Austin1, A Connelly, D G Gadian
1Sub-Department of Academic Radiology, Institute of Child Health, London, England.
Magnetic Resonance in Medicine
|June 1, 1991
Abstract:
Two children with Canavan's Disease, an autosomal recessive leukodystrophy, were studied by localized 1H spectroscopy. The N-acetylaspartate (NAA) signal intensity was high relative to other metabolite signals, and the signal intensity from choline-containing compounds was low. These findings are discussed in relation to a possible role for NAA in normal myelination.