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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

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Endometrial stromal sarcoma: a population-based analysis.

J K Chan1, N M Kawar, J Y Shin

  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, San Francisco School of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA. chanjohn@obgyn.ucsf.edu

British Journal of Cancer
|September 25, 2008
PubMed
Summary
This summary is machine-generated.

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Prognostic factors for endometrial stromal sarcoma (ESS) survival include age, race, stage, grade, and surgery. Grade 3 ESS significantly impacts survival, unlike grades 1 and 2. Ovarian-sparing surgery is safe for younger patients with early-stage disease.

Area of Science:

  • Gynecologic Oncology
  • Cancer Epidemiology
  • Surgical Oncology

Background:

  • Endometrial stromal sarcoma (ESS) is a rare uterine malignancy.
  • Understanding prognostic factors is crucial for patient management and survival prediction.

Purpose of the Study:

  • To identify independent prognostic factors for survival in patients diagnosed with endometrial stromal sarcoma (ESS).
  • To evaluate the impact of tumor grade and surgical approach on patient outcomes.

Main Methods:

  • Data from 831 patients diagnosed with ESS between 1988-2003 were analyzed using the National Cancer Institute's SEER database.
  • Kaplan-Meier and Cox proportional hazards models were employed to determine survival.
  • Multivariate analysis identified independent prognostic factors.

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Last Updated: Jun 30, 2026

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

Main Results:

  • Advanced stage (III-IV) and higher tumor grade (grade 3) were associated with significantly poorer survival (5-year DSS 50.3% vs 89.3% for stage I-II; 42.1% survival for grade 3 vs 91.4-95.4% for grades 1-2).
  • Independent prognostic factors for poorer survival included older age, black race, advanced stage, higher grade, lack of primary surgery, and nodal metastasis.
  • Ovarian-sparing procedures in younger women (<50 years) with early-stage disease did not adversely affect survival.

Conclusions:

  • Age, race, primary surgery, stage, and grade are significant prognostic indicators for ESS.
  • ESS with grade 1 and 2 tumors exhibit excellent survival across all stages, distinguishing them from grade 3 tumors.
  • Ovarian-sparing surgery is a viable option for younger patients with early-stage ESS.