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Related Experiment Video

Updated: Jun 30, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Correlation between migraine subtypes and depression.

Renan Barros Domingues¹, Esther Angélica Coelho Costa, Ariovaldo da Silva

¹Headache Clinic, Escola Superior de Ciências da Saúde de Vitória, Vitória, ES, Brazil. renan-domingues@uol.com.br

Arquivos De Neuro-Psiquiatria

|September 25, 2008

Summary

Migraine patients show higher depression scores, confirming a link between migraine and depression. However, depression doesn't appear to drive migraine chronification or medication overuse.

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Last Updated: Jun 30, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Investigating Migraine-Like Behavior Using Light Aversion in Mice

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Published on: August 11, 2021

Area of Science:

Neurology
Psychiatry
Clinical Research

Background:

Migraine is a prevalent neurological disorder.
Depression is frequently observed alongside migraine, suggesting a potential comorbidity.
The relationship between depression, migraine chronification, and medication overuse requires further elucidation.

Purpose of the Study:

To evaluate and compare depressive symptoms in patients with episodic migraine, chronic migraine without medication overuse, and chronic migraine with medication overuse.
To investigate the role of depression in the transformation of episodic migraine to chronic migraine.
To explore the association between depression and medication overuse in chronic migraine patients.

Main Methods:

Utilized the Beck Depression Inventory (BDI) for symptom assessment.
Compared BDI scores across three distinct patient cohorts: episodic migraine, chronic migraine without medication overuse, and chronic migraine with medication overuse.
Included a comparison group of asymptomatic subjects.

Main Results:

Patients with all forms of migraine exhibited significantly higher mean Beck Depression Inventory scores compared to asymptomatic individuals.
No significant difference in median BDI scores was found between patients with episodic migraine and chronic migraine.
Median BDI scores were similar between patients with chronic migraine with medication overuse and those without medication overuse.

Conclusions:

A significant comorbidity exists between migraine and depression.
Depression does not appear to be a critical factor in the progression from episodic to chronic migraine.
Medication overuse behavior in chronic migraine patients does not seem to be directly related to depression levels.