Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence that specific high mannose structures directly regulate multiple cellular activities.

N Sathyamoorthy1, J M Decker, A P Sherblom

  • 1Metabolism Branch, NCI, NIH, Bethesda, MD.

Molecular and Cellular Biochemistry
|April 10, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C-type natriuretic peptide modulates bidirectional plasticity in hippocampal area CA1 in vitro.

Neuroscience·2010
Same author

C-type natriuretic peptide decreases hippocampal network oscillations in adult rats in vitro.

Neuroscience·2009
Same author

Severe gastrointestinal disease due to HIV-1-seronegative AIDS.

Zeitschrift fur Gastroenterologie·2007
Same author

Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection.

Journal of virology·2007
Same author

Genotoxicity and carcinogenicity studies of soy isoflavones.

International journal of toxicology·2002
Same author

Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptor.

Journal of virology·2001
Same journal

High glucose-induced mitochondrial fission promotes Müller cell activation via suppression of the Hippo pathway.

Molecular and cellular biochemistry·2026
Same journal

Correction to: Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein.

Molecular and cellular biochemistry·2026
Same journal

Galectin-3, transforming growth factor beta 1, and brain natriuretic peptide in cardiac remodeling under hyperlipidemic and hyperglycemic stress.

Molecular and cellular biochemistry·2026
Same journal

Ellagic acid from the traditional Chinese medicinal herb Scutellaria barbata may accelerates apoptosis in hepatic stellate cells during liver fibrosis via inhibiting miR-182-5p.

Molecular and cellular biochemistry·2026
Same journal

GeneQuantify: a web-based tool for qPCR gene expression and copy number variation analysis.

Molecular and cellular biochemistry·2026
Same journal

NCAPG reprograms glycolytic and lipid metabolism by sustaining glycerophospholipid flux in small-cell lung cancer.

Molecular and cellular biochemistry·2026
See all related articles

Specific mannose oligosaccharides, found in natural sources, can modulate immune responses. These compounds activate key immune pathways and cellular responses, suggesting a role in regulating immunity.

Area of Science:

  • Immunology
  • Glycobiology
  • Carbohydrate Chemistry

Background:

  • Uromodulin's immunomodulatory activity is linked to its oligosaccharides.
  • A specific structure, Man6GlcNAc2-asn, inhibits T cell proliferation in vitro.

Purpose of the Study:

  • To investigate the biological activity of high mannose glycopeptides.
  • To determine if mannose-rich structures regulate immune responses.

Main Methods:

  • Isolation of high mannose glycopeptides from natural sources.
  • In vitro assays measuring hexose monophosphate (HMP) shunt activation, prostaglandin synthesis, and IL-1 synthesis.
  • In vivo studies assessing mononuclear cell infiltration after intradermal injection.

Main Results:

Related Experiment Videos

  • Purified mannose-rich glycopeptides activated the HMP shunt, induced prostaglandin synthesis, and stimulated IL-1 synthesis in vitro.
  • High mannose compounds induced a species-restricted delayed mononuclear cell infiltrate in vivo.
  • Specific mannose oligosaccharides demonstrated both activation and inhibition of cellular immune responses.

Conclusions:

  • Specific mannose oligosaccharides possess significant immunomodulatory properties.
  • These findings support the hypothesis that saccharide structures play a physiological role in immune response regulation.