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Updated: Jun 30, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Transitional cell carcinoma of the bladder in first decade of life
Ramnik Patel1, Tim Tery, George K Ninan
1Department of Paediatric Urology, Children's Hospital, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Infirmary Road, Leicester, LE1 5WW, UK.
Abstract:
This report describes two rare cases of well-differentiated, non-invasive transitional cell carcinomas in children (Grade 1 Stage pTa). One was 8-year-old girl with a polypoid lesion and the other 9-year-old girl with kissing bilateral paraureteral lesions. The initial presentation was haematuria and symptoms of urinary tract infection. Subsequent course and investigation confirmed the diagnosis. Complete resection of the lesion and follow-up with urine cytology, vesical ultrasound and check cystoscopy at 4 years has showed no evidence of recurrence.
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