[Pulmonary veno-occlusive disease - a rare form of pulmonary arterial hypertension]
Related Experiment Video
Updated: Jun 30, 2026

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
Published on: November 18, 2018
M Halank1, M Kolditz, S Langner
1Bereich Pneumologie, Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Dresden. Michael.Halank@uniklinikum-dresden.de
Abstract:
Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. So far some 200 cases have been published worldwide. Since the latest classification, agreed at a meeting in Venice in 2003, PVOD is included in the group of pulmonary arterial hypertension (PAH). It has been hypothesized that it represents endothelial dysfunction of unknown cause. Although it has many features in common with idiopathic PAH, it partially differs from it phenotypically. After exclusion of known causes of pulmonary hypertension, such as diseases of pulmonary interstitial tissue, acral clubbing and rales suggest PVOD. The findings typical in the computed tomogram of the chest include prominent septal lines, centro-acinar opacities and mediastinal lymphadenopathy. In addition to arterial lesions PVOD is particularly characterized by lesions in the venous vascular bed. PVOD has a poor prognosis. Treatment with medication approved for PAH may carry the risk of pulmonary edema. Currently the immediate listing for lung- or combined lung-heart-transplantation is recommended, once the diagnosis of PVOD has been established.
Related Concept Videos
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Pulmonary Embolism I: Introduction
Pulmonary Embolism I: Introduction
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Portal Hypertension

