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Updated: Jun 30, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Binding of DNA nucleobases and nucleosides with graphene
Neenu Varghese1, Umesha Mogera, Achutharao Govindaraj
1Chemistry and Physics of Materials Unit, DST nanoscience unit and CSIR Centre of Excellence in Chemistry, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P. O., Bangalore 560064, India.
Abstract:
Interaction of two different samples of graphene with DNA nucleobases and nucleosides is investigated by isothermal titration calorimetry. The relative interaction energies of the nucleobases decrease in the order guanine (G)>adenine (A)>cytosine (C)>thymine (T) in aqueous solutions, although the positions of C and T seem to be interchangeable. The same trend is found with the nucleosides. Interaction energies of the A-T and G-C pairs are somewhere between those of the constituent bases. Theoretical calculations including van der Waals interaction and solvation energies give the trend G>A approximately T>C. The magnitudes of the interaction energies of the nucleobases with graphene are similar to those found with single-walled carbon nanotubes.
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