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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Interferon-alpha therapy does not modulate hepatic expression of classical type I interferon inducible genes

Volker Meier1, Sabine Mihm, Giuliano Ramadori

  • 1Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Georg-August-University Goettingen, Goettingen, Germany.

Journal of Medical Virology
|September 25, 2008
PubMed
Summary

Hepatitis C virus (HCV) treatment with interferon-alpha(2) (IFN-alpha(2)) induces type I IFN regulated genes in blood cells, but not in the liver. This suggests HCV clearance mechanisms may not involve hepatic type I IFN gene activation.

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