Antagonistic effect of low deprenyl dose on the preimplantation embryo development in rat

To investigate the role of potent MAO-B inhibitor deprenyl in fertilized females, we have evaluated the effect of chronic treatment with deprenyl at a low dosage on preimplantation embryo development in Wistar rats. We have found that the number of isolated embryos per rat did not differ between experimental and control groups. But morphological analysis of embryos isolated from deprenyl-treated animals had revealed improved rates in the distribution pattern compared with controls. On the other hand, harmful impact of deprenyl administration on the mean cell number in blastocysts and on their cell proliferation has been recorded. To our knowledge this is the first paper describing antagonistic effect of deprenyl administration on the preimplantation embryo development in mammals. Potential mechanisms mediating biphasic deprenyl-induced impact on embryonic development are proposed (Tab. 3, Ref. 17). Full Text (Free, PDF) www.bmj.sk.