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A Simple Fecal Flotation Method for Diagnosing Zoonotic Nematodes Under Field and Laboratory Conditions
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A Simple Fecal Flotation Method for Diagnosing Zoonotic Nematodes Under Field and Laboratory Conditions

Published on: December 15, 2023

Current trends in tissue-affecting helminths.

B Gottstein1, R Piarroux

  • 1Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. bruno.gottstein@ipa.unibe.ch

Parasite (Paris, France)
|September 26, 2008
PubMed
Summary
This summary is machine-generated.

This study explores how Echinococcus multilocularis, Trichinella spiralis, and Toxocara conis evade host immunity. It highlights the role of host reactions in parasite control and immunopathology, validating the mouse model for human infection relevance.

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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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Published on: August 22, 2012

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Last Updated: Jun 30, 2026

A Simple Fecal Flotation Method for Diagnosing Zoonotic Nematodes Under Field and Laboratory Conditions
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

Area of Science:

  • Parasitology
  • Immunology
  • Helminthology

Background:

  • Helminths exhibit complex strategies to invade host organisms and establish infection.
  • Parasitic helminths evolve mechanisms to evade host immune responses for survival, maturation, and proliferation.
  • Understanding these evasion strategies is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the survival strategies of three distinct helminths: Echinococcus multilocularis, Trichinella spiralis, and Toxocara conis.
  • To elucidate the role of periparasitic host reactions in parasite control and host immunopathology.
  • To assess the suitability of the murine model for studying these helminths in the context of human infections.

Main Methods:

  • Comparative analysis of immune evasion strategies employed by Echinococcus multilocularis, Trichinella spiralis, and Toxocara conis.
  • Examination of host immune responses at the site of infection.
  • Evaluation of immunopathological consequences in the host.
  • Validation of the murine model by comparing parasite life cycles in rodents and humans.

Main Results:

  • Echinococcus multilocularis, Trichinella spiralis, and Toxocara conis utilize unique strategies to survive within host organs or cells.
  • Periparasitic host reactions play a dual role, aiding in parasite control while potentially causing harmful immunopathology.
  • The murine model is confirmed as a relevant experimental system for these helminths due to shared infection patterns with humans.

Conclusions:

  • The study provides insights into the sophisticated immune evasion tactics of key helminth parasites.
  • Host immune responses are critical determinants of both parasite burden and disease severity.
  • Findings from murine models offer reliable data for understanding human helminth infections, particularly for Echinococcus multilocularis, Trichinella spiralis, and Toxocara conis.