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Updated: Jun 30, 2026
07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Signet-ring cell carcinoma arising from the urinary bladder.
Imre Romics1, Eszter Székely, Attila Szendroi
1Department of Urology, Semmelweis University, Budapest, Hungary.
The Canadian Journal of Urology
|September 26, 2008
Summary
Primary signet-ring cell carcinoma of the urinary bladder is rare but treatable. This case study highlights successful management with radical cystectomy and adjuvant chemotherapy, achieving a 5-year disease-free survival.
Area of Science:
- Urology
- Oncology
Background:
- Signet-ring cell carcinoma (SRCC) of the urinary bladder is exceptionally rare, with fewer than 100 reported cases.
- It can be primary or metastatic, with primary tumors arising from bladder or urachal remnants.
Observation:
- A 45-year-old woman presented with gross hematuria and a necrotic bladder tumor.
- Transurethral biopsy confirmed primary signet-ring cell carcinoma of the bladder.
Findings:
- The patient underwent radical cystectomy with ureterosigmoidostomy and received adjuvant chemotherapy (cisplatin and fluorouracil).
- Histological staging was pT3bN0M0.
- Primary SRCC of the bladder accounts for about 0.24% of bladder malignancies.
Implications:
- Despite a generally poor prognosis for primary bladder SRCC, this case demonstrates a positive long-term outcome.
- Successful management involves radical surgery and adjuvant chemotherapy.
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