Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Circulatory disorders induced by amantidine].

M Cloarec, B Singer, B Mignot

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |April 9, 1976
    PubMed
    Summary

    Amantadine, used for Parkinson's disease since 1969, can cause lower limb symptoms. Capillaroscopy reveals this drug-induced micro-circulation abnormality, specifically arteriolar and venular vasoconstriction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    What is the potential benefit of pre-hospital extracorporeal cardiopulmonary resuscitation for patients with an out-of-hospital cardiac arrest? A predictive modelling study.

    Resuscitation·2023
    Same author

    Characteristics of adolescents with chronic poorly controlled type 1 diabetes - A qualitative study.

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2022
    Same author

    Quantitative CT analysis using functional imaging is superior in describing disease progression in idiopathic pulmonary fibrosis compared to forced vital capacity.

    Respiratory research·2018
    Same author

    IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia.

    Mucosal immunology·2017
    Same author

    Patient-rated ease of use and functional reliability of an electronic autoinjector for self-injection of subcutaneous interferon beta-1a for relapsing multiple sclerosis.

    Multiple sclerosis and related disorders·2015
    Same author

    Rebif(®) Quality of Life (RebiQoL): A randomized, multicenter, Phase IIIb study evaluating quality-of-life measures in patients receiving the serum-free formulation of subcutaneous interferon beta-1a for the treatment of relapsing forms of multiple sclerosis.

    Multiple sclerosis and related disorders·2015

    Area of Science:

    • Neurology
    • Pharmacology
    • Microcirculation

    Context:

    • Amantadine has been a treatment for Parkinson's disease since 1969.
    • Specific lower limb symptoms associated with amantadine were noted in 1970.
    • Previous literature describes various disturbances related to amantadine use.

    Purpose:

    • To investigate the micro-circulatory disturbances in the lower limbs caused by amantadine.
    • To analyze 10 cases using Capillaroscopy to understand drug-induced effects.
    • To highlight the significance of studying micro-circulation abnormalities in amantadine therapy.

    Summary:

    • The study reviewed known disturbances associated with amantadine.
    • Capillaroscopy was employed to examine 10 patients experiencing amantadine-related symptoms.

    Related Experiment Videos

  • Findings indicate amantadine induces vasoconstriction in arterioles and venules, affecting micro-circulation.

    • Impact:

    • Emphasizes the clinical relevance of Capillaroscopy in detecting amantadine side effects.
    • Provides insight into the mechanism of amantadine-induced peripheral vascular changes.
    • Suggests monitoring micro-circulatory function in patients on long-term amantadine treatment.