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Updated: Jun 30, 2026

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis

M P Kim1, S I Park, S Kopetz

  • 1Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box no. 173, Houston, TX 77030-4009, USA.

Cell and Tissue Research
|September 26, 2008
PubMed

Insights

Src family kinases (SFKs) regulate cell functions and vascular biology. Aberrant SFK activation drives inflammation and cancer metastasis by affecting endothelial permeability, with inhibitors showing therapeutic promise.

Area of Science:

  • Cellular biology
  • Molecular signaling
  • Vascular biology

Background:

  • Src family kinases (SFKs) are crucial signaling enzymes regulating cell proliferation, survival, migration, and metastasis.
  • SFKs play significant roles in normal and pathological vascular processes, including endothelial cell proliferation and permeability.
  • Dysregulated SFK activity contributes to inflammatory conditions and tumor metastasis.

Purpose of the Study:

  • To review the role of aberrantly activated SFKs in mediating endothelial permeability.
  • To discuss the involvement of SFKs in inflammatory states and tumor cell metastasis.
  • To summarize therapeutic strategies targeting SFKs.

Main Methods:

  • Literature review of studies on SFKs in vascular biology and cancer.
  • Analysis of mechanisms by which SFKs regulate endothelial permeability.
  • Summary of clinical efforts to develop SFK inhibitors.

Main Results:

  • Aberrantly activated SFKs significantly increase endothelial permeability.
  • SFKs contribute to inflammation and metastasis through endothelial barrier dysfunction.
  • SFK inhibitors are being investigated for treating inflammatory diseases and cancers.

Conclusions:

  • SFKs are key mediators of endothelial permeability in disease.
  • Targeting SFKs offers a potential therapeutic avenue for inflammatory and metastatic conditions.
  • Further research into SFK inhibitors is warranted for clinical translation.

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