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Neutrophil as a mediator of ischemic edema formation in the brain
1Department of Neurology, Tohoku University, School of Medicine, Sendai, Japan.
Neuroscience Letters
|April 29, 1991
Abstract:
We investigated the contribution of neutrophils to brain edema formation using a transient focal ischemia model in rats. Rats were given anti-neutrophil monoclonal antibody (RP3) intraperitoneally to deplete circulating neutrophils. In RP3-treated rats, ischemic brain edema formation 1 day after reperfusion was significantly decreased compared to that of saline-treated control rats. We speculate that chemical mediators released by infiltrating neutrophils alter vascular permeability and play an important role in post-ischemic brain edema formation.