Sister Mary Joseph's nodule: Three case reports

Area of Science:

• Oncology
• Gastroenterology
• Urology

Background:

• Sister Mary Joseph's nodule is a rare clinical finding representing an umbilical metastatic lesion.
• It is infrequently the initial presentation of an underlying malignant disease.

Purpose of the Study:

• To report three cases of Sister Mary Joseph's nodule.
• To emphasize the differential diagnosis of umbilical lesions.

Main Methods:

• Case series reporting three instances of Sister Mary Joseph's nodule.
• Review of patient histories and diagnostic findings.

Main Results:

• The primary tumors in the presented cases were adenocarcinoma of the sigmoid colon, bladder carcinoma, and adenocarcinoma of the gallbladder.
• These cases illustrate the diverse origins of umbilical metastases.

Conclusions:

• Umbilical lesions warrant a differential diagnosis that includes metastatic disease.
• Metastatic nodules to the umbilicus can originate from various primary sites, including gastrointestinal and genitourinary malignancies.