Sister Mary Joseph's nodule: Three case reports
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Updated: Jun 30, 2026

A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules
Published on: May 19, 2023
Andreas Larentzakis1, Dimitrios Theodorou, Klio Fili
11st Department of Propaedeutic Surgery, Hippokrateion General Hospital, Athens Medical School, University of Athens, Q, Sofias 114 av,, 11527, Athens, Greece. alarentz@med.uoa.gr.
Background:
An umbilical metastatic lesion is called 'Sister Mary Joseph's nodule'. It is an uncommon clinical or radiographic finding, and it is rare as the first sign of a malignant disease.
Case Presentation:
We report three cases of Sister Mary Joseph's nodule. In the three cases presented, the primary tumor was an adenocarcinona of the sigmoid colon, a carcinoma of the bladder, and an adenocarcinoma of the gallbladder, respectively.
Conclusion:
The differential diagnosis of an umbilical lesion should always include metastatic disease apart from benign lesions and primary neoplasms.
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