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Updated: Jun 30, 2026
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Structures and solvatochromic phosphorescence of dicationic terpyridyl-platinum(II) complexes with foldable
Ming-Xin Zhu1, Wei Lu, Nianyong Zhu
1Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong (China).
Abstract:
A series of binuclear organoplatinum(II) complexes, [(tBu3tpy)Pt--(C[triple chemical bond]C--1,2-C6H4)n--C[triple chemical bond]C--Pt(tBu3tpy)][ClO4]2 (1-7, n=1, 2, 3, 4, 5, 6, 8; tBu3tpy=4,4',4''-tri-tert-butyl-2,2':6',2''-terpyridine) with foldable oligo(ortho-phenyleneethynylene) linkers were prepared and characterized by spectroscopic methods and/or X-ray crystallographic analyses. In the crystal structures of 32.5 CH3OH, 5CH3CN, and 64 CH3CN, each of the bridging ortho-phenyleneethynylene ligands has a partially folded conformation. In aerated water/acetonitrile mixtures with water percentages larger than 40 %, the emission of complexes 3-7 are red-shifted and enhanced when compared to those recorded in acetonitrile. The red-shift in emission energy and enhanced emission intensity can be attributed to the inter- and/or intramolecular interactions induced by the addition of water to solutions of the platinum(II) complexes in acetonitrile. Data from dynamic light scattering and transmission electron microscopy studies revealed that these binuclear platinum(II) complexes aggregated into nanosized particles in acetonitrile/water mixtures. Hydrophobic folding of the ortho-phenyleneethynylene linkers in acetonitrile/water mixtures is postulated.
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