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Endoscopic findings and Helicobacter pylori in children on long-term hemodialysis

Fakhrossadat Mortazavi1, Mandana Rafeey

  • 1Department of Pediatric Nephrology, Faculty of Medicine, Liver and Gastroenterology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Pakistan Journal of Biological Sciences : PJBS
|September 27, 2008
PubMed

Insights

Gastrointestinal issues and Helicobacter pylori infection are common in children with End Stage Renal Disease (ESRD) on hemodialysis. Pre-transplant upper GI evaluation is crucial for these pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Infectious Diseases

Background:

  • End Stage Renal Disease (ESRD) impacts multiple organ systems, including the gastrointestinal (GI) tract.
  • Children undergoing maintenance hemodialysis face unique health challenges.
  • Limited data exists on GI pathology and Helicobacter pylori infection in pediatric ESRD patients.

Purpose of the Study:

  • To determine the prevalence of GI symptoms.
  • To assess endoscopic abnormalities and histologic gastritis.
  • To evaluate Helicobacter pylori infection rates in children with ESRD before renal transplantation.

Main Methods:

  • Upper endoscopy and gastric biopsies were performed on 31 pediatric ESRD patients.
  • Helicobacter pylori status was assessed using urease testing and histology.
  • Data on patient demographics, dialysis duration, and clinical symptoms were collected.

Main Results:

  • 54.8% of patients experienced GI symptoms, and 64.5% had endoscopic abnormalities.
  • Common findings included antral erythema, esophagitis, and diffuse gastritis.
  • H. pylori infection was present in 64.5% of patients, with no correlation to age, sex, or symptoms.

Conclusions:

  • A high prevalence of endoscopic abnormalities and H. pylori infection exists in pediatric ESRD patients.
  • Endoscopic findings were more frequent in symptomatic patients.
  • Upper GI evaluation is recommended for ESRD children prior to renal transplantation.

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