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Palmitoylation controls recycling in lysosomal sorting and trafficking

Peter J McCormick1, Karine Dumaresq-Doiron, Anne-Sophie Pluviose

  • 1Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Traffic (Copenhagen, Denmark)
|September 27, 2008
PubMed
Summary

Palmitoylation is crucial for lysosomal receptors like sortilin and cation-independent mannose 6-phosphate receptor to traffic correctly. This modification ensures their interaction with retromer for efficient recycling and cargo delivery.

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