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Technique to Target Microinjection to the Developing Xenopus Kidney
Published on: May 3, 2016
An ontology for Xenopus anatomy and development
Erik Segerdell1, Jeff B Bowes, Nicolas Pollet
1Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada. esegerde@ucalgary.ca
BMC Developmental Biology
|September 27, 2008
Summary
A new Xenopus anatomical ontology organizes frog development and tissue lineage. This structured vocabulary aids Xenopus gene expression and phenotype data annotation in model organism databases.
Area of Science:
- Amphibian developmental biology
- Comparative genomics
- Bioinformatics
Background:
- Xenopus laevis and Xenopus (Silurana) tropicalis are key model organisms in genetics and developmental biology.
- Xenbase centralizes genetic and genomic data, including gene function from screens and literature.
- A structured vocabulary is crucial for organizing Xenopus anatomical and developmental data.
Purpose of the Study:
- To create a standardized anatomical ontology for Xenopus.
- To facilitate data organization and retrieval for Xenopus research.
Main Methods:
- Development of a hierarchical ontology for Xenopus anatomy.
- Classification of anatomical features within a common framework.
- Adoption of the ontology by multiple model organism databases.
Main Results:
- A comprehensive Xenopus anatomical ontology has been constructed.
- The ontology represents tissue lineage and developmental timing.
- It is available via the Open Biomedical Ontologies Foundry.
Conclusions:
- The Xenopus Anatomical Ontology will annotate gene expression and phenotypes.
- The developmental map supports advanced database searches and analysis.
- Community input is encouraged for ontology refinement.
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