Related Experiment Video
Updated: Jun 30, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
Published on: April 16, 2015
CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?
Einar Martin Aandahl1, Knut Martin Torgersen, Kjetil Taskén
1The Biotechnology Centre of Oslo, University of Oslo, N-0317 Oslo, Norway.
Abstract:
Regulation of the immune system is fundamental for proper immune function and homeostasis. In the periphery, regulatory T cells provide self-tolerance and protect the host from harmful autoreactive T cells. Regulatory T cells are also involved in the pathogenesis of chronic viral infectious diseases and cancer. Both the CD4(+) and the CD8(+) T cell compartments contain regulatory T cells. Although various CD4(+) regulatory T-cell subsets represent the best characterized regulatory T-cell populations, CD8(+) regulatory T cells also have strong immunosuppressive properties and are involved in the pathogenesis of various clinical conditions. In this review, we will discuss the phenotypic and functional characteristics of CD8(+) regulatory T cells in comparison to CD4(+) regulatory T cells.
Related Concept Videos
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cells of the Adaptive Immune Response
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Lineage Commitment
