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Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: Jun 30, 2026

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
09:57

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

Published on: January 29, 2019

CD8+ suppressor T cells resurrected.

Judith A Kapp1, R Pat Bucy

  • 1Department of Ophthalmology and Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. jkapp@uab.edu

Human Immunology
|September 27, 2008
PubMed
Summary
This summary is machine-generated.

Antigen-specific T cells actively inhibit immune responses. Research evolved from CD8(+) suppressor cells to Foxp3(+) regulatory T cells, with induced T cells playing a key role in immune suppression.

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Area of Science:

  • Immunology
  • Cellular immunology

Background:

  • The concept of suppressor T cells has evolved significantly over 35 years.
  • Initial theories suggested CD8(+) T cells mediated suppression, followed by skepticism, and later the identification of Foxp3 as a critical regulator.

Purpose of the Study:

  • To review the role of antigen-specific T cells in active immune inhibition.
  • To discuss the paradigm shifts in understanding suppressor/regulatory T cell function.
  • To highlight recent findings on induced regulatory T cells and their mechanisms.

Main Methods:

  • Review of scientific literature over the past 35 years.
  • Analysis of data from transgenic T cell receptor (TCR Tg) models.
  • Focus on transcription factor Foxp3 and cytokine-induced T cell regulation.

Main Results:

  • Foxp3(+) T cells, particularly CD4(+)CD25(+) cells, are key orchestrators of immune suppression.
  • Antigen and specific cytokines like TGF-beta can induce Foxp3 expression and suppressive function in both CD4(+) and CD8(+) T cells.
  • Induced T cells suppress immune responses by inhibiting antigen-presenting cell costimulation and cytokine production.

Conclusions:

  • Antigen-specific T cells, including induced populations, are crucial for active immune inhibition.
  • Understanding these regulatory mechanisms is vital for controlling immune responses.
  • Further research emphasizes "linked suppression" and the comparative efficacy of different suppressive pathways.