Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of potent HLA-A02:01-restricted peptide-based cytotoxic T-cells against SARS-CoV-2 infections in patients awaiting a kidney transplant.

Frontiers in immunology·2025

Same author

Clinical Safety and Preliminary Efficacy of Regulatory T Cells for ALS.

NEJM evidence·2025

Same author

A novel HLA-B*58:141 allele identified by next-generation sequencing in a potential hematopoietic cell recipient.

HLA·2023

Same author

Optical genome mapping in acute myeloid leukemia: a multicenter evaluation.

Blood advances·2022

Same author

Previous SARS-CoV-2 infection or a third dose of vaccine elicited cross-variant neutralising antibodies in vaccinated solid-organ transplant recipients.

Clinical & translational immunology·2022

Same author

Impact of bone marrow minimal residual disease status on quality of organ response in systemic AL amyloidosis.

American journal of hematology·2022

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

CD8+ T suppressor cells and the ILT3 master switch.

George Vlad¹, Raffaello Cortesini, Nicole Suciu-Foca

¹Columbia University, Department of Pathology, New York, NY 10032, USA.

Human Immunology

|September 27, 2008

Summary

CD8(+) T suppressor cells use immunoglobulin-like transcript 3 (ILT3) to induce tolerance. This interaction regulates immune responses in transplantation, autoimmunity, allergy, and cancer.

Area of Science:

Immunology
Cellular Biology
Molecular Medicine

Background:

CD8(+) T suppressor cells (Ts) are crucial immune regulators.
Antigen-presenting cells (APCs) interact with T cells to establish immune responses.
Immunoglobulin-like transcript 3 (ILT3) is an inhibitory receptor expressed on APCs.

Purpose of the Study:

To review the central role of ILT3 in CD8(+) T cell-mediated suppression.
To elucidate the mechanism by which ILT3 regulates T cell responses.
To highlight the implications of ILT3 in various immune-mediated diseases.

Main Methods:

Literature review of studies investigating CD8(+) Ts, APCs, and ILT3.
Analysis of evidence linking ILT3 upregulation to T cell suppression.

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Related Experiment Videos

Last Updated: Jun 30, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Synthesis of data on ILT3's function in different immunological contexts.

Main Results:

CD8(+) Ts induce ILT3 expression on APCs through direct cell-cell interaction.
ILT3 expression on APCs promotes a tolerogenic phenotype.
Tolerogenic APCs differentiate additional regulatory and suppressor T cells.

Conclusions:

ILT3 is the key mediator of CD8(+) T suppressor cell function.
ILT3 acts as a master switch controlling CD8(+) and CD4(+) T cell responses.
Targeting ILT3 may offer therapeutic strategies for transplantation, autoimmunity, allergy, and cancer.