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CRISPR/Cas9 Technology in Restoring Dystrophin Expression in iPSC-Derived Muscle Progenitors
07:44

CRISPR/Cas9 Technology in Restoring Dystrophin Expression in iPSC-Derived Muscle Progenitors

Published on: September 14, 2019

Dystrophin knockdown mice suggest that early, transient dystrophin expression might be enough to prevent later

Dongsheng Duan1

  • 1Department of Molecular Microbiology and Immunology, School of Medicine, The University of Missouri, One Hospital Dr., Columbia, MO 65212, USA. duand@missouri.edu

Neuromuscular Disorders : NMD
|September 27, 2008
PubMed
Abstract

No abstract available in PubMed .

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

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