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Updated: Jun 30, 2026
06:07
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
HIV immunopathogenesis and strategies for intervention
Martin Cadogan1, Angus G Dalgleish
1Laboratory of Oncology, Department of Cellular and Molecular Medicine, St George's University of London, Tooting, London, UK. m_cadogan@hotmail.com
The Lancet. Infectious Diseases
|September 27, 2008
Summary
Accessible HIV therapies remain limited, hindering treatment for many. Novel strategies, including therapeutic vaccines targeting immune activation, are crucial for combating the human immunodeficiency virus (HIV) pandemic.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Therapeutic options for the human immunodeficiency virus (HIV) pandemic are limited by accessibility and affordability, leaving many untreated.
- HIV's evolutionary escape mechanisms impede antiviral efficacy and vaccine development.
- Understanding of HIV pathogenesis is shifting from viral cytopathy to immunopathogenic features, particularly generalized immune activation in Acquired immunodeficiency syndrome (AIDS) development.
Purpose of the Study:
- To review current perspectives on HIV-induced pathogenic immune activation.
- To explore novel strategies for HIV elimination and therapeutic vaccine development.
Main Methods:
- Literature review of current scientific opinion on HIV pathogenesis and therapeutic strategies.
- Analysis of the role of immune activation in HIV disease progression.
- Evaluation of potential therapeutic vaccine approaches.
Main Results:
- Conventional vaccine strategies focusing on viral neutralization and cellular responses have limitations.
- HIV-induced immune activation is a critical factor in AIDS pathogenesis.
- Non-neutralizing antibodies may play a role in future therapeutic vaccine strategies.
Conclusions:
- Novel therapeutic strategies are needed to overcome HIV treatment and vaccine development barriers.
- Addressing HIV-induced immune activation is essential for effective intervention.
- Therapeutic vaccines incorporating non-neutralizing antibodies represent a promising avenue for HIV management.
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