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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

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Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
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Published on: January 23, 2009

Cell therapy in peripheral arterial disease.

Ibhar Al Mheid1, Arshed A Quyyumi

  • 1Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Angiology
|September 27, 2008
PubMed
Summary

Cell therapy offers a promising new treatment for advanced peripheral arterial disease when other methods fail. This approach aims to alleviate severe ischemic symptoms in patients with leg circulation issues.

Area of Science:

  • Vascular Medicine
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Advanced obstructive vascular disease of the extremities presents significant clinical challenges.
  • Peripheral arterial disease (PAD) commonly results from atherosclerosis but can stem from nonatherosclerotic causes like Buerger's disease.
  • PAD complications range from claudication to limb-threatening ischemia, including ulceration, gangrene, and amputation.

Purpose of the Study:

  • To explore the potential of cell therapy as a treatment for intractable ischemic symptoms in advanced peripheral arterial disease.
  • To evaluate a novel therapeutic strategy for patients with peripheral arterial disease who have exhausted conventional treatments.

Main Methods:

  • Utilized a cell therapy approach for patients with peripheral arterial disease.

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Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
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Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
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  • Focused on subjects with intractable ischemic symptoms unresponsive to standard medical and revascularization therapies.

    • Main Results:

    • Cell therapy demonstrated promise in managing severe ischemia associated with peripheral arterial disease.
    • This innovative treatment addresses symptoms when conventional options are no longer effective.

    Conclusions:

    • Cell therapy represents a new and hopeful avenue for treating advanced peripheral arterial disease.
    • This therapeutic modality offers a potential solution for patients with refractory ischemic conditions in the extremities.