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Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

Carolina Maestre1, Maria Delgado-Esteban, Jose C Gomez-Sanchez

  • 1Unidad de Investigación, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y León, Salamanca, Spain.

The EMBO Journal
|September 27, 2008
PubMed
Summary

The anaphase-promoting complex/cyclosome (APC/C) regulates neuronal survival. Cdk5-mediated Cdh1 phosphorylation stabilizes cyclin B1, causing neuronal death in neurodegenerative diseases.

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