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Updated: Feb 5, 2026
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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
Published on: July 27, 2021
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Eosinophils and their interactions with respiratory virus pathogens.
Helene F Rosenberg1, Kimberly D Dyer, Joseph B Domachowske
1Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C215, Bethesda, MD 20892, USA. hrosenberg@niaid.nih.gov
Immunologic Research
|September 27, 2008
Summary
Eosinophils, often linked to airway issues, may also combat respiratory viruses. Research shows they can reduce virus infectivity and aid in clearing certain pathogens.
Area of Science:
- Immunology
- Virology
- Respiratory Medicine
Background:
- Eosinophils are typically associated with negative roles in respiratory virus infections, such as exacerbating asthma symptoms.
- However, emerging evidence suggests potential protective functions of eosinophils against viral pathogens.
Purpose of the Study:
- To investigate the dual role of eosinophils in respiratory virus infections.
- To explore the interaction between pneumonia virus of mice (PVM) and eosinophils.
Main Methods:
- In vitro experiments assessing virus infectivity.
- In vivo mouse challenge models using respiratory syncytial virus (RSV) and PVM.
- Analysis of PVM replication and cytokine release within eosinophils.
Main Results:
- Eosinophils demonstrated an ability to reduce virus infectivity in cell cultures.
- Eosinophils promoted the clearance of respiratory syncytial virus in a mouse model.
- Pneumonia virus of mice (PVM) replicates within eosinophils and induces cytokine release, suggesting a complex interaction.
Conclusions:
- Eosinophils possess both detrimental and beneficial roles in the context of respiratory viral infections.
- The interaction between PVM and eosinophils warrants further investigation to understand its impact on disease pathogenesis.
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