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Clinical observations programme in SpA: disease parameters, treatment options and practical management issues
Dirk Elewaut1, Filip Van den Bosch, Gust Verbruggen
1Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. dirk.elewaut@ugent.be
Rheumatology International
|September 27, 2008
Summary
Spondyloarthritides (SpAs) are chronic inflammatory diseases. TNFalpha inhibitors offer a new treatment approach, targeting underlying inflammation to manage symptoms and potentially alter disease progression.
Area of Science:
- Rheumatology
- Immunology
- Inflammatory Diseases
Background:
- Spondyloarthritides (SpAs) encompass chronic inflammatory rheumatic diseases.
- These conditions involve joint/tendon inflammation, radiographic changes, and extra-articular features.
- Current treatments manage symptoms but do not halt disease progression.
Purpose of the Study:
- To evaluate the potential of TNFalpha inhibitors in treating SpAs.
- To explore the impact of TNFalpha blockade on disease progression.
- To assess the efficacy of TNFalpha inhibitors in managing extra-articular manifestations.
Main Methods:
- Review of existing literature on TNFalpha inhibitors in SpA treatment.
- Analysis of clinical trial data for efficacy and safety.
- Examination of the mechanism of action of TNFalpha blockade.
Main Results:
- TNFalpha inhibitors target the underlying inflammatory pathology of SpAs.
- These agents demonstrate potential in altering disease progression.
- Effective management of extra-articular manifestations is achievable with TNFalpha blockade.
Conclusions:
- TNFalpha inhibitors represent a significant advancement in SpA management.
- Targeting TNFalpha offers a disease-modifying approach.
- This therapy holds promise for comprehensive SpA treatment, including extra-articular symptoms.
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