Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

Area of Science:

• Hematology
• Oncology
• Pathology

Background:

• Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma.
• Splenic involvement in DLBCL can occur, but primary red pulp involvement is less understood.
• Understanding distinct DLBCL subtypes is crucial for accurate diagnosis and treatment.

Purpose of the Study:

• To characterize the clinicopathological features of DLBCL involving the splenic red pulp.
• To determine if primary splenic red pulp DLBCL represents a distinct clinicopathological entity.

Main Methods:

• Retrospective analysis of six cases of DLBCL with red pulp splenic involvement.
• Clinical data review, including symptoms, disease course, and organ involvement.
• Pathological examination of tissue samples, including immunohistochemistry (CD5 expression).

Main Results:

• All six patients presented with B symptoms and aggressive disease.
• Lymphoma cells infiltrated the splenic red pulp diffusely.
• Bone marrow and liver involvement were common; lymph node involvement was rare at presentation.
• Peripheral blood involvement and CD5 expression were observed in a subset of patients.

Conclusions:

• Primary splenic DLBCL manifesting in the red pulp exhibits unique clinical and pathological features.
• These findings suggest it may represent a distinct clinicopathological entity.
• Further research is warranted to confirm its distinctness and guide therapeutic strategies.