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Adverse effects of parenteral antimicrobial therapy for chronic bone infections

C Pulcini1, T Couadau, E Bernard

  • 1Service d'Infectiologie, Hôpital de l'Archet 1, Centre Hospitalier Universitaire de Nice , BP 3079, 06202, Nice, France.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|September 27, 2008
PubMed

Insights

Adverse effects are common in patients with chronic bone infections (CBI) receiving parenteral antimicrobial therapy, impacting over a third of individuals. These complications stem from both the implantable port and the antibiotic treatments used.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Orthopedics

Background:

  • Chronic bone infections (CBI) often involve resistant pathogens, necessitating parenteral antimicrobial therapy.
  • Parenteral antimicrobial therapy can lead to adverse effects, impacting patient outcomes.
  • Implantable ports are frequently used for long-term parenteral drug administration in CBI patients.

Purpose of the Study:

  • To determine the rate of adverse effects associated with parenteral antimicrobial therapy for chronic bone infections.
  • To identify the types and frequencies of complications related to implantable ports and antibiotic agents in CBI patients.

Main Methods:

  • Retrospective study of patients receiving parenteral antimicrobial drugs via an implantable port for CBI.
  • Inclusion of patients from medical and surgical wards between January 1995 and December 2005.
  • Analysis of catheter-related and antibiotic-related complications, remission rates, and factors influencing adverse effects.

Main Results:

  • Thirty-three catheter-related complications (21%) and twenty-one antibiotic-related complications (16%) were observed.
  • One death occurred due to an allergic reaction to antibiotics.
  • Remission was achieved in 65% of patients, with adverse effects more frequent in the medical department.

Conclusions:

  • Adverse effects impact at least one-third of patients undergoing parenteral antimicrobial therapy for CBI.
  • Complications are associated with both the implantable port and the antibiotic compounds used.
  • Careful monitoring and management are crucial to mitigate risks in CBI treatment.

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