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Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
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HRQoL after coronary artery bypass grafting and percutaneous coronary intervention for stable angina

Pertti Loponen1, Michael Luther, Kari Korpilahti

  • 1Department of Thoracic and Vascular Surgery, Vaasa Central Hospital, Vaasa, Finland. pertti.loponen@pp.inet.fi

Scandinavian Cardiovascular Journal : SCJ
|September 27, 2008
PubMed

Insights

Coronary artery bypass grafting (CABG) patients experienced better symptom relief and quality of life improvements compared to percutaneous coronary intervention (PCI) patients in stable coronary artery disease management over 36 months.

Area of Science:

  • Cardiovascular Medicine
  • Quality of Life Research

Background:

  • Stable coronary artery disease (CAD) management involves invasive treatments like CABG and PCI.
  • Assessing health-related quality of life (HRQoL) and symptom burden is crucial for patient outcomes.

Purpose of the Study:

  • To compare HRQoL and NYHA class changes between CABG and PCI in stable CAD patients.
  • To evaluate mid-term and long-term outcomes following these interventions.

Main Methods:

  • Non-randomized study comparing 240 CABG patients with 229 PCI patients.
  • Prospective HRQoL assessment using the 15D instrument.
  • Follow-up included survival rates and NYHA class evaluation.

Main Results:

  • Three-year survival rates were similar (95.0% CABG vs. 95.6% PCI).
  • HRQoL improved in both groups by 6 months but declined by 36 months.
  • CABG patients showed more frequent clinically significant HRQoL improvements and NYHA class reduction.

Conclusions:

  • CABG patients achieved comparable HRQoL to PCI patients despite a more severe preoperative state.
  • CABG may offer better symptom relief in the mid-term follow-up.
  • HRQoL is important but should be considered alongside overall clinical status in CAD treatment decisions.
Abstract

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