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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Inflammation01:38

Inflammation

Overview
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
09:44

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The neutrophilic dermatoses.

David Farhi1, Daniel Wallach

  • 1Dermatology and Venereology Department, Tarnier-Cochin Hospital, Paris, France.

Dermatology Nursing
|September 30, 2008
PubMed
Summary

Neutrophilic dermatoses (ND) involve skin inflammation from neutrophils, not infection. This review covers their management and nursing care for associated systemic diseases.

Area of Science:

  • Dermatology
  • Immunology
  • Internal Medicine

Background:

  • Neutrophilic dermatoses (ND) are inflammatory skin conditions.
  • Characterized by neutrophils in skin lesions without infection.
  • Often linked to systemic diseases.

Purpose of the Study:

  • To review the management of neutrophilic dermatoses.
  • To highlight the importance of nursing care in managing ND patients.

Main Methods:

  • Literature review on neutrophilic dermatoses.
  • Analysis of clinical presentations and associations.
  • Focus on therapeutic strategies and nursing interventions.

Main Results:

  • ND present with diverse skin lesions like pustules and plaques.

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Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions

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ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
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ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils

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Detecting Migration and Infiltration of Neutrophils in Mice
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Detecting Migration and Infiltration of Neutrophils in Mice

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Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions
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  • Polymorphonuclear leukocytes are key in pathogenesis.
  • Management requires addressing underlying systemic conditions.
  • Conclusions:

    • Neutrophilic dermatoses necessitate comprehensive patient management.
    • Integrated medical and nursing care is crucial for optimal outcomes.
    • Understanding ND pathogenesis aids in effective treatment strategies.