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[Tissue factor molecules and some other indices of coagulation hemostasis in patients with rheumatic heart disease]

V V Gorbunov, S Iu Tsarenok, I V Rosin

    Klinicheskaia Meditsina
    |September 30, 2008
    PubMed

    This comparative study of interleukins, tissue factor activity, and certain parameters of coagulation hemostasis included patients with rheumatic heart disease. It revealed an increased production of proinflammatory cytokines including interleukin-1b (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in all groups of patients. The procoagulative activity was also enhanced and positively correlated with the IL-1 beta level. Tissue factor activity was directly proportional to the concentration of IL-1 beta and inversely proportional to that of interleukin-4 (IL-4).

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