Related Experiment Video
Updated: Jun 30, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
A 10 month old infant with nystagmus and strabismus
Attary S Jedari1, Z Maliky, Kh Daneshjou
1Department of Pediatrics, Imam Khomeini Hospital, Tehran University of Medical Science, Tehran, Iran.
Insights
Congenital toxoplasmosis can manifest solely as nystagmus and strabismus in infants. Early diagnosis is crucial, as this parasitic infection may present with subtle ocular findings and brain calcifications.
Area of Science:
- Ophthalmology
- Pediatrics
- Infectious Diseases
Background:
- Congenital toxoplasmosis is a significant cause of visual impairment in children.
- Early detection and treatment are vital to prevent long-term complications.
Observation:
- A 10-month-old infant presented with nystagmus and strabismus following a five-month history of fever.
- Ophthalmoscopy revealed characteristic salt-and-pepper retinopathy and scars.
- Brain CT scan demonstrated multiple intracranial calcifications.
Findings:
- Diagnosis was confirmed by a high titer of serum anti-Toxoplasma antibodies (IgG > 400).
- The clinical presentation highlighted the potential for toxoplasmosis to cause isolated ocular abnormalities.
Implications:
- This case underscores the importance of considering congenital toxoplasmosis in the differential diagnosis of abnormal infant eye movements.
- Prompt recognition can lead to timely intervention, potentially mitigating severe visual and neurological sequelae.
Abstract:
This report present an infant with nystagmus, strabismus, salt and pepper and scars in funduscopy, calcification in Brain CT scan and high titer of Anti Toxoplasmosis antibody. A 10 month old infant that referred with nystagmus, strabismus after fever which appeared five months ago. In funduscopy of both eyes, salt and pepper and scars and in Brain CT scan multiple calcification were seen. The diagnosis of congenital Toxoplasmosis was established by positive serum Anti toxoplasma Ab (IgG) (> 400). Toxoplasmosis may present with only nystagmus and strabismus and physicians should consider this infection in the differential diagnosis of a abnormal eye movement.
Related Concept Videos
Photoreceptors and Visual Pathways
Accessory Structures of the Eye

