Related Experiment Video
Updated: Jun 30, 2026
05:32
A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device
Published on: November 24, 2016
[Excessive sweating related to hydromorphone].
J Vinit1, H Devilliers, S Audia
1Service de médecine interne et maladies systémiques, hôpital Général, CHU de Dijon, 3, rue Faubourg-Raines, 21000 Dijon, France. levine_julien@yahoo.com
La Revue De Medecine Interne
|September 30, 2008
Summary
Excessive sweating can signal serious conditions like lymphoma. However, this case highlights hydromorphone, an opiate, as a potential cause of severe sweating.
Area of Science:
- Medical Science
- Pharmacology
- Oncology
Background:
- Diffuse and abundant sweating persisting for weeks warrants investigation for serious underlying conditions.
- Differential diagnoses include malignant lymphoma, infectious diseases, and neuroendocrine disorders.
Observation:
- A middle-aged patient presented with severe, debilitating excessive sweating.
- The sweating was linked to hydromorphone therapy for vertebral pain.
Findings:
- Excessive sweating is a known, albeit less common, side effect of certain opioid analgesics.
- The patient's sweating resolved upon discontinuation of hydromorphone, suggesting a drug-induced etiology.
Implications:
- Clinicians should consider medication side effects, particularly opioids like hydromorphone, in the differential diagnosis of persistent hyperhidrosis.
- This case underscores the importance of a thorough medication review in patients with unexplained excessive sweating.
Related Concept Videos
01:29Disorder of Water Balance
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
01:30Toxidromes: Clinical Features
Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
01:21Hyperosmolar Hyperglycemic State
Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
01:26Regulation of Water Output
The human body predominantly expels water through the urinary system. On average, an individual generates around 1.5 liters of urine each day. This amount can fluctuate based on how well a person is hydrated, but a critical minimum quantity of urine must be produced to ensure the body's proper functioning. Daily, the kidneys remove 600 to 1200 milliosmoles of dissolved substances, effectively excreting excess minerals and water-soluble toxins such as creatinine, urea, and uric acid from the...
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
01:19Homeostatic Imbalances in Body Temperature
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...