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Related Experiment Video

Updated: Jun 30, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Pathodiagnostic parameters for meningioma grading.

A Moradi1, V Semnani, H Djam

  • 1Cancer Research Center, Shahid Beheshty University of Medical Sciences, Shohada Teaching Hospital, Tajrish Square, Tehran 19317, Iran. madani_68@yahoo.com

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|September 30, 2008
PubMed
Summary
This summary is machine-generated.

The mitotic count is the most crucial factor in determining meningioma tumor grade. This study analyzed pathodiagnostic parameters and MIB-1 expression in 378 meningiomas over 10 years.

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Published on: January 9, 2019

Area of Science:

  • Neuropathology
  • Oncology

Background:

  • Meningiomas are typically slow-growing tumors, but complete surgical removal can be challenging, leading to recurrence.
  • Accurate grading of meningiomas is essential for predicting prognosis and guiding treatment strategies.

Purpose of the Study:

  • To assess the relationship between pathodiagnostic parameters, histological grade, and MIB-1 expression in meningiomas.
  • To re-evaluate meningioma diagnoses according to the latest World Health Organization (WHO) Classification.

Main Methods:

  • Retrospective analysis of 378 meningiomas diagnosed between 1997 and 2006.
  • Histopathological review of hematoxylin and eosin stained slides by two independent pathologists.
  • Classification of histological grade (I, II, III) based on WHO Working Group 2000 criteria.

Main Results:

  • No significant relationship was found between tumor location and histopathological features.
  • Strong associations were observed between mitotic rate, cellularity, nucleo-cytoplasmic ratio, and sheet-like spreading.
  • Tumor grade correlated with loss of architecture, mitotic figures, cellularity, nucleo-cytoplasmic ratio, prominent nucleolus, brain invasion, and necrosis.

Conclusions:

  • Mitotic count emerged as the most significant marker for meningioma tumor grade.
  • Histopathological features are critical for grading and predicting the behavior of meningiomas.