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[Mifepristone modulates glucosylceramide synthase expression and reverse multidrug resistance in ovarian cancer

Ying Liu1, Li-li Wang

  • 1Department of Obstetrics and Gynecology, Guangdong Provincial People's Hospital, Guangzhou, China.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|September 30, 2008
PubMed
Abstract

Insights

Mifepristone can reduce multidrug resistance (MDR) in ovarian cancer cells by lowering cisplatin resistance. This effect is linked to the drug

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Context:

  • Ovarian cancer frequently develops multidrug resistance (MDR) to chemotherapy.
  • Glucosylceramide synthase (GCS) is implicated in MDR.
  • Developing strategies to overcome MDR is crucial for improving patient outcomes.

Purpose:

  • To investigate the efficacy of mifepristone in reversing MDR in human ovarian cancer cells (COC(1)/DDP).
  • To determine mifepristone's effect on glucosylceramide synthase (GCS) mRNA expression in these cells.

Summary:

  • MDR ovarian cancer cells (COC(1)/DDP) showed significantly higher GCS mRNA expression compared to sensitive cells.
  • Mifepristone treatment (1.25-10 µmol/L) enhanced chemosensitivity to cisplatin.
  • Mifepristone demonstrated a dose-dependent inhibition of GCS mRNA expression.

Impact:

  • Mifepristone effectively reduces cisplatin resistance in ovarian cancer cells.
  • The mechanism involves the dose-dependent inhibition of GCS expression.
  • This finding suggests mifepristone as a potential therapeutic agent to overcome MDR in ovarian cancer.

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