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Related Concept Videos

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...

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Updated: Jun 30, 2026

Exploring the Longissimus Muscle: Unraveling its Correlation with Meat Quality in Bos indicus and Crossbred Bulls
07:46

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Gene expression patterns during intramuscular fat development in cattle.

Y H Wang1, N I Bower, A Reverter

  • 1Commonwealth Scientific and Industrial Research Organisation (CSIRO) Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Rd., St. Lucia, Queensland 4067, Australia. yonghong.wang@csiro.au

Journal of Animal Science
|September 30, 2008
PubMed
Summary
This summary is machine-generated.

Researchers identified early molecular markers for predicting beef marbling potential in cattle. Gene expression in young Wagyu x Hereford crosses showed higher adipogenesis and lipogenesis activity, distinguishing them from less marbled Piedmontese x Hereford crosses.

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Isolation of Nuclei from Human Intermuscular Adipose Tissue and Downstream Single-Nuclei RNA Sequencing

Published on: May 3, 2024

Area of Science:

  • Animal Science
  • Genetics
  • Meat Science

Background:

  • Intramuscular fat (marbling) significantly impacts beef quality (juiciness, flavor, tenderness).
  • Marbling is influenced by genetics, age, and nutrition in cattle.
  • Early prediction of marbling capacity is crucial for optimizing beef production.

Purpose of the Study:

  • To identify genes acting as early biomarkers for marbling capacity in cattle.
  • To investigate the muscle transcriptome differences between high and low marbling potential crossbreeds.
  • To determine the earliest age at which molecular differences in marbling can be detected.

Main Methods:

  • Comparative transcriptome profiling of Wagyu x Hereford (WxH) and Piedmontese x Hereford (PxH) crossbreed heifers.
  • Utilized complementary DNA microarray and quantitative reverse transcription-PCR.
  • Collected Longissimus dorsi (LM) muscle biopsies from birth (3 months) through slaughter (30 months).

Main Results:

  • Identified 97 differentially expressed genes between WxH and PxH crossbreeds.
  • Distinguished high marbling potential (WxH) from low (PxH) transcriptomes as early as 7 months of age.
  • Observed higher expression of adipogenesis/lipogenesis genes in young WxH, and mitochondrial oxidative genes in PxH.

Conclusions:

  • Early molecular changes associated with marbling are detectable via gene expression.
  • Specific lipogenesis-related genes (ADIPOQ, SCD, THRSP) correlate with intramuscular fat content.
  • Findings enable optimized nutrition strategies and development of genetic markers for beef production.