The newborn with seizures -- a follow-up study
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Updated: Jun 30, 2026

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
Published on: June 11, 2020
Mary Iype1, Maya Prasad, P M C Nair
1Department of Neurology and Pediatrics, SAT Hospital, Medical College Trivandrum, Kerala, India. tvm_agkoshy@sancharnet.in
Objective:
To determine the sequelae of neonatal seizures in a cohort of newborns, recruited over a six month period.
Design:
Prospective hospital based study.
Setting:
The neonatal intensive care unit (NICU) of a tertiary care hospital.
Participants:
135 babies were recruited of whom 10 died and 25 were lost to follow up.
Methods:
The cases were followed up over four months.
Results:
68% of the babies followed up were normal; 32% had an abnormal neurological outcome. Seven (7%) developed post-neonatal epilepsy. Hypocalcemia was significantly associated with mortality (OR: 21.9; 95% CI: 1.2-391.2). No risk factors could be identified for post neonatal epilepsy. Presence of spike waves in the EEG was significantly related to abnormal neurological outcome (OR: 3.5; 95% C.I. 1.2-10.8).
Conclusions:
Majority of neonates with seizures have a normal outcome with no developmental delay or neurological deficit. Predominantly spike waves in the EEG is predictive of abnormal neurological outcome.
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