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Related Concept Videos

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Intestinal Obstruction II: Pathophysiology

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Related Experiment Video

Updated: Jun 30, 2026

Tissue Engineering of the Intestine in a Murine Model
08:45

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Published on: December 1, 2012

Permanent intestinal failure.

Olivier Goulet1, Fabio Fusaro, Florence Lacaille

  • 1National Reference Center for Rare Digestive Diseases, Hospital Necker Enfants Malades, Universite Paris 5 Rene Descartes, Paris, France. olivier.goulet@nck.aphp.fr

Indian Pediatrics
|September 30, 2008
PubMed
Summary

Plasma citrulline aids in evaluating intestinal failure (IF), a condition often requiring parenteral nutrition or intestinal transplantation. Management strategies for IF are evolving, particularly for pediatric short bowel syndrome (SBS).

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Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Clinical Nutrition

Background:

  • Intestinal failure (IF) necessitates parenteral nutrition and may lead to intestinal transplantation.
  • Pediatric short bowel syndrome (SBS) is a primary cause of IF in infants, with limited epidemiological data.
  • Other IF causes include neuromuscular intestinal disease and congenital enterocyte development disorders.

Purpose of the Study:

  • To review the causes and management of intestinal failure (IF).
  • To highlight the role of plasma citrulline in assessing intestinal mass.
  • To emphasize the importance of multidisciplinary care for IF patients.

Main Methods:

  • A comprehensive literature search was conducted using both electronic and manual methods.
  • Review of existing data on the epidemiology, morbidity, and mortality of pediatric IF, particularly SBS.
  • Analysis of current therapeutic strategies and the role of specialized centers.

Main Results:

  • Plasma citrulline is emerging as a viable marker for biological evaluation of IF.
  • Epidemiological data and long-term outcomes for pediatric SBS are improving but remain limited.
  • Multidisciplinary approaches and timely referral to specialized centers are crucial for IF management.

Conclusions:

  • Plasma citrulline offers a new avenue for assessing intestinal mass in IF.
  • Effective IF management requires tailored, multidisciplinary care in specialized centers.
  • Optimizing the timing of referral to specialized centers is critical for improving patient outcomes.