Related Experiment Video
Updated: Jun 30, 2026

Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Oropharyngeal cancer
Amanda Psyrri1, Loukas Prezas, Barbara Burtness
1Head and Neck Oncology Unit, Yale University School of Medicine, New Haven, CT 06520, USA. diamando.psyrri@yale.edu
Abstract:
Carcinoma of the oropharynx is of squamous histology in over 90% of cases. Oropharyngeal squamous cell carcinoma (OSCC) displays significant heterogeneity in terms of etiology, biology, and clinical behavior. It has now become clear that a subset is initiated by infection with high-risk human papillomavirus (HPV) types, especially type 16. This review summarizes the epidemiology, clinical presentation, molecular pathogenesis, diagnosis, and therapy of OSCC, focusing on the HPV-associated cases; it also details the need for a better understanding of the molecular pathogenesis of the different types of OSCC in order to improve treatment.
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