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Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Hybrid CABG: an alternative for perfusion time decrease
Jackson Brandão Lopes1, Luiz Boro Puig, Luis Alberto Oliveira Dallan
1Faculdade de Medicina, Universidade de São Paulo. jackson.lopes@incor.usp.br
Insights
The hybrid technique significantly reduces cardiopulmonary bypass (CPB) time and postoperative complications like atrial fibrillation and renal dysfunction in coronary artery bypass grafting (CABG). This method offers a safer alternative for cardiac surgery.
Area of Science:
- Cardiovascular Surgery
- Minimally Invasive Cardiac Surgery
Background:
- Coronary Artery Bypass Grafting (CABG) is a common procedure.
- Cardiopulmonary Bypass (CPB) is associated with potential complications.
Purpose of the Study:
- To evaluate the efficacy of a hybrid technique in reducing CPB time.
- To assess the impact of the hybrid technique on related postoperative complications in CABG.
Main Methods:
- Retrospective analysis of 90 patients undergoing CABG with three or more grafts.
- Comparison between a hybrid technique group (45 patients) and a conventional on-pump group (45 patients).
Main Results:
- The hybrid group exhibited significantly shorter CPB and aorta cross-clamping times compared to the total group (p<0.001).
- A statistically significant reduction in postoperative atrial fibrillation and renal dysfunction was observed in the hybrid group.
Conclusions:
- The hybrid technique effectively reduces CPB time in CABG.
- This reduction in CPB time may lead to decreased incidences of atrial fibrillation and renal dysfunction, potentially due to reduced inflammatory response.
Objective:
To evaluate the decrease of CPB time and its related complications in CABG using a hybrid alternative method.
Methods:
Ninety patients were retrospectively analyzed between March 2000 and August 2006. All were treated with three or more grafts and divided into two groups: Group 1 was the hybrid group--45 patients who had been operated by the hybrid technique; Group 2 was the total group--45 patients operated in on-pump.
Results:
In the hybrid group, the CPB time varied from 20 min. to 81 min. In the total group, the CPB time varied from 60 min. to 210 min. (p<0.001). The aorta cross-clamping time varied in the first group from 7 min. to 70 min. In Group 2, from 34 to 100 min. (p<0.001). A statistically significant difference was found between these two groups in relation to the occurrence of postoperative atrium fibrillation and renal dysfunction.
Conclusion:
Using the hybrid technique it is possible to reduce the CPB time, as well as the occurrence of some postoperative complications. Probably, this decreasing in atrial fibrillation and renal dysfunction incidences could be explained due to a less significant inflammatory activation, which is a consequence of a shorter CPB time.

