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Recombineering Homologous Recombination Constructs in Drosophila
Published on: July 13, 2013
Re-creation of the genetic composition of a founder population
William Klitz1, Martin Maiers, Loren Gragert
1University of California, Berkeley, USA. klitz@berkeley.edu
Abstract:
Human ethnic groups are frequently comprised of two or more founder populations. One of these founding populations is often available for contemporary sampling. We describe a method for reconstructing the composition of a missing founder population using the highly informative haplotypes comprising the HLA system. An application of the method is demonstrated using bone marrow registry samples of African Americans. We use contemporary samples of African Americans and European Americans to derive haplotypes of the West African founder populations. This approach may also be useful for reconstructing ancestral haplotypes for regions elsewhere in the genome.
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